Not to mention the different ways you can play one individual note. Bending, muting, etc.
I don't think we'll ever run out of new music. Djent has only been around for a few years, and when it immerged it was something completely new and fresh. We may hear recurring chord progressions, but the delivery and emotion behind it will always be different.
There are no two humans alike. No exact matches. How could we ever run out of variables to keep creating?