Have you checked out Uriah's site? Good stuff (figured I'd plug it for him).
Personally, I would suggest studying your minor pentatonics (blues scales), because those will fit almost anything. I'm going to post a thing on them soon. Also the hybrid pentatonics (which are basically you monir pent and major pent crammed together--I'll hit those, too).
Also, work on your major scales, because not everything can be played with blues scales, but it gets you in pretty good.
Well, I should ask, by "runs" do you mean little fillers between the chords, or all-out lead?
AND, welcome to LGM, by the way.